amino acid diversity of antigenic sites of iranian type o foot-and-mouth disease virus

Antigenic sites on foot-and-mouth disease virus type A10.

A set of monoclonal antibodies was used to isolate nonneutralizable foot-and-mouth disease virus variants, and the RNAs of the variants were sequenced. Cross-neutralization studies and mapping of the amino acid changes indicated two major antigenic sites. The first site was trypsin sensitive and included the VP1 140 to 160 sequence. The second site was trypsin insensitive and included mainly VP...

Organic Circulation and persistence of Foot – and – Mouth disease virus type O in guinea pig

Since, the most susceptible laboratory animal to Foot–and–Mouth disease virus (FMDV) is guinea pig, and then one milliliter of FMDV type (O) concentrations of 106-106.5 TCID50was inoculated intradermally (ID) to 10 plantar surface of guinea pig (right side). Guinea pig adapted virus has been prepared after generalization phase, and then one milliliter of virus was inoculated intradermally to 30...

Molecular Cloning of VPI gene of Foot-and-Mouth Disease Virus Type 01/Iran

Extensive antigenic diversification of foot-and-mouth disease virus by amino acid substitutions outside the major antigenic site.

The antigenic sites A and C (the G-H loop and the C terminus, respectively) in VP1 of foot-and-mouth disease virus (FMDV) have been considered the immunodominant regions of the virus involved in the induction of protection. Other antigenic sites have been described but their involvement in protection has not been established. Here we report that two closely related but serologically different F...

organic circulation and persistence of foot – and – mouth disease virus type o in guinea pig

since, the most susceptible laboratory animal to foot–and–mouth disease virus (fmdv) is guinea pig, and then one milliliter of fmdv type (o) concentrations of 106-106.5 tcid50was inoculated intradermally (id) to 10 plantar surface of guinea pig (right side). guinea pig adapted virus has been prepared after generalization phase, and then one milliliter of virus was inoculated intradermally to 30...

Tracking the Antigenic Evolution of Foot-and-Mouth Disease Virus

Quantifying and predicting the antigenic characteristics of a virus is something of a holy grail for infectious disease research because of its central importance to the emergence of new strains, the severity of outbreaks, and vaccine selection. However, these characteristics are defined by a complex interplay of viral and host factors so that phylogenetic measures of viral similarity are often...